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SESN1 Antibody (MA5-38000) in IHC (P)
Immunohistochemistry analysis of SESN1 in paraffin-embedded human colon carcinoma. Samples were incubated with SESN1 Monoclonal antibody (Product # MA5-38000) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-38000
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2313
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human sestrin 1 (Q9Y6P5)
偶联物
形式
Liquid
浓度
0.83 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897918
产品详细信息
Positive Samples: HepG2, PC-3
Immunogen sequence: KTQHYLLQMD GPLPLHYRHY IGIMAAARHQ CSYLVNLHVN DFLHVGGDPK WLNGLENAPQ KLQNLGELNK VLAHRPWLIT KEHIEGLLKA EEHSWSLAEL V
靶标信息
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; Sestrin-1
基因别名: 1110002G11Rik; AU044290; PA26; SESN1; SEST1
UniProt ID: (Human) Q9Y6P5, (Mouse) Q7TNF3
Entrez Gene ID: (Human) 27244, (Mouse) 140742
