Invitrogen

SFRP1 Recombinant Rabbit Monoclonal Antibody (ARC1683)

高级验证

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

1 篇参考文献
查看其他15个SFRP1抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

MA5-38193

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
查看1篇已发表文章 1篇已发表文章

酶联免疫吸附实验 (ELISA)

1 µg/mL
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

ARC1683

抗原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SFRP1 (Q8N474)
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.88 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898110

产品详细信息

Positive Samples: U-251MG, Mouse kidney, Rat testis, Rat kidney

Immunogen sequence: MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ SDIGPYQSGR FYTKPPQCVD IPADLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL

靶标信息

Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in several human tissues, with the highest levels in heart.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: frizzled-related protein; FRP-1; SARP-2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; secreted frizzled-related sequence protein 1; sFRP-1

查看更多 收起

基因别名: 2210415K03Rik; AW011917; AW107218; AW742929; FRP; FRP-1; FRP1; FrzA; SARP2; sFRP-1; SFRP1

查看更多 收起

UniProt ID: (Human) Q8N474, (Mouse) Q8C4U3

查看更多 收起

Entrez Gene ID: (Human) 6422, (Mouse) 20377, (Rat) 84402

查看更多 收起

功能
cysteine-type endopeptidase activity G-protein coupled receptor activity frizzled binding protein binding drug binding heparin binding Wnt-protein binding identical protein binding Wnt-activated receptor activity molecular_function transmembrane signal receptor
参与通路
osteoblast differentiation ureteric bud development positive regulation of cell-matrix adhesion hematopoietic progenitor cell differentiation proteolysis G-protein coupled receptor signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation male gonad development female gonad development cellular response to starvation dorsal/ventral axis specification regulation of cell cycle process negative regulation of gene expression negative regulation of epithelial to mesenchymal transition neural crest cell fate commitment response to organic cyclic compound menstrual cycle phase positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of ossification positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration negative regulation of BMP signaling pathway negative regulation of osteoblast proliferation somatic stem cell population maintenance response to drug positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity positive regulation of GTPase activity cellular response to fibroblast growth factor stimulus stromal-epithelial cell signaling involved in prostate gland development negative regulation of B cell differentiation positive regulation of fat cell differentiation negative regulation of osteoblast differentiation negative regulation of osteoclast differentiation regulation of angiogenesis positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of insulin secretion negative regulation of bone remodeling negative regulation of fibroblast proliferation digestive tract morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation positive regulation of stress fiber assembly positive regulation of focal adhesion assembly canonical Wnt signaling pathway hematopoietic stem cell differentiation bone trabecula formation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis negative regulation of androgen receptor signaling pathway cellular response to vitamin D cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to prostaglandin E stimulus cellular response to estrogen stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to X-ray cellular response to heparin dopaminergic neuron differentiation cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure Wnt signaling pathway involved in somitogenesis convergent extension involved in somitogenesis positive regulation of canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of dopaminergic neuron differentiation midbrain morphogenesis negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of non-canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of fibroblast apoptotic process positive regulation of fibroblast apoptotic process somitogenesis neural tube closure multicellular organism development anterior/posterior pattern specification Wnt signaling pathway neural tube development actin cytoskeleton organization hemopoiesis cell differentiation regulation of ossification substrate adhesion-dependent cell spreading development of primary male sexual characteristics Wnt signaling pathway, planar cell polarity pathway regulation of establishment of planar polarity positive regulation of extrinsic apoptotic signaling pathway non-canonical Wnt signaling pathway
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持