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SFRP4 Antibody (PA5-19067) in IHC (P)
Immunohistochemistry analysis of SFRP4 in human skeletal muscle, interstitial cells. Samples were incubated with SFRP4 polyclonal antibody (Product # PA5-19067) using a dilution of 3.75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
产品信息
PA5-19067
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (TNSSCQCPHILPHQD) corresponding to the internal amino acids of SFRP4 (aa 239-254).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10983342
产品详细信息
This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Frizzled protein, human endometrium; FrpHE; MGC26498; Secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; sFRP-4
基因别名: FRP-4; FRPHE; sFRP-4; SFRP4
UniProt ID: (Human) Q6FHJ7
Entrez Gene ID: (Human) 6424
positive regulation of receptor internalization
G-protein coupled receptor signaling pathway
multicellular organism development
negative regulation of cell proliferation
response to hormone
positive regulation of gene expression
cell differentiation
negative regulation of Wnt signaling pathway
non-canonical Wnt signaling pathway
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of epidermal cell differentiation
phosphate ion homeostasis
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
mitophagy in response to mitochondrial depolarization
positive regulation of keratinocyte apoptotic process
negative regulation of sodium-dependent phosphate transport
