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SFTPC Antibody (PA5-119603) in WB
Frontiers in physiology 2022 -
FIGURE 5 Effects of uc.375 overexpression and FoxA1 overexpression on the function of MLE 12 cells. (A) The proliferation activity of MLE 12 cells was detected by CCK-8 assay. (B) The cell apoptosis was determined by Hoechst/PI staining in MLE 12 cells. (C) The protein levels of caspase3, FoxA1, SP-C and UCP2 were investigated by western blot in MLE 12 cells. (D) The cell apoptosis was determined using low ... View More
产品信息
PA5-119603
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat,
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SFTPC.
偶联物
Unconjugated
形式
Liquid
浓度
1.04 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2913176
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BRICHOS domain containing 6; PSP C; pulmonary surfactant apoprotein-2 SP-C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SFTP 2; SP C; SP-C; SP5; surfactant associated protein C; Surfactant protein C; Surfactant pulmonary-associated protein C; Surfactant, pulmonary-associated protein C
基因别名: BRICD6; pro-SpC; PSP-C; Sftp-2; SFTP2; SFTPC; SMDP2; SP-C; SP5; SPC
UniProt ID: (Human) P11686, (Rat) P11685
Entrez Gene ID: (Human) 6440, (Mouse) 20389, (Rat) 50683
respiratory gaseous exchange
cellular protein metabolic process
protein homooligomerization
circadian rhythm
response to hormone
response to glucose
response to organic substance
response to lipopolysaccharide
response to retinoic acid
response to vitamin A
regulation of liquid surface tension
response to glucocorticoid
response to cAMP
response to hyperoxia
response to interleukin-6
response to growth factor
cellular response to mechanical stimulus
cellular response to nitric oxide
