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A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Medulla oblongata-derived protein; MGC17342; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23
基因别名: hmob33; MOB; MOB1; SGMS1; SMS1; TMEM23
UniProt ID: (Human) Q86VZ5
Entrez Gene ID: (Human) 259230