Search Thermo Fisher Scientific
By Western blot, PA1-12722 detects a ~64 kDa protein representing S1P lyase 1 from MDBK cell lysate.
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ13811; hSPL; mSPL; S1PL; SP-lyase 1; sphingosine phosphate lyase 1; Sphingosine-1-phosphate aldolase; Sphingosine-1-phosphate lyase 1; SPL 1
基因别名: AI428538; D10Xrf456; KIAA1252; S1PL; SGPL1; Spgl1; SPL
UniProt ID: (Human) O95470, (Mouse) Q8R0X7, (Rat) Q8CHN6
Entrez Gene ID: (Human) 8879, (Bovine) 522515, (Mouse) 20397, (Rat) 286896