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SHARPIN Antibody (PA5-99964) in IHC (P)
Immunohistochemistry analysis of SHARPIN in mouse stomach tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SHARPIN polyclonal antibody (Product # PA5-99964) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99964
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SHARPIN(Accession Q9H0F6), corresponding to amino acid residues G66-V116.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818897
产品详细信息
Antibody detects endogenous levels of total SHARPIN.
靶标信息
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hSIPL1; mSIPL1; protein kinase C-interacting protein RBCC like 1; SHANK-associated RH domain interacting protein; SHANK-associated RH domain interactor; Shank-associated RH domain-interacting protein; shank-interacting protein; Shank-interacting protein-like 1; Sharpin
基因别名: 0610041B22Rik; AW121341; Conneck1; Cpdm; PSEC0216; RBCKL1; SHARPIN; SIPL1
UniProt ID: (Human) Q9H0F6, (Rat) Q9EQL9, (Mouse) Q91WA6
Entrez Gene ID: (Human) 81858, (Rat) 81859, (Mouse) 106025
mitochondrion organization
I-kappaB kinase/NF-kappaB signaling
brain development
regulation of tumor necrosis factor-mediated signaling pathway
apoptotic nuclear changes
keratinization
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of inflammatory response
protein homooligomerization
protein linear polyubiquitination
regulation of CD40 signaling pathway
epidermis development
