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产品信息
PA5-60390
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.08 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647272
产品详细信息
Immunogen sequence: QCLHTIQTED RVWSIAISPL LSSFVTGTAC CGHFSPLRIW DLNSGQLMTH LGSDFPPGAG VLDVMYESPF TLLSCGYD
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 95%.
靶标信息
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
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生物信息学
蛋白别名: Dactylin; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; F-box/WD repeat protein 4; F-box/WD repeat-containing protein 4
基因别名: DAC; FBW4; FBWD4; FBXW4; SHFM3; SHSF3
UniProt ID: (Human) P57775
Entrez Gene ID: (Human) 6468
