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产品信息
PA5-47210
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse SIGNR1 Ser76-Gly325
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606891
产品详细信息
In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse (rm) SIGNR3 and rmSIGNR4 is observed, and approximately 10% cross-reactivity with recombinant human DC-SIGNR and rmDC-SIGN is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD209; CD209 antigen-like protein A; CD209 antigen-like protein B; DC SIGNR1; DC-SIGN; DC-SIGN-related protein 1; DC-SIGNR1; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC130443; OtB7
基因别名: 1810030I22Rik; CD209; Cd209a; Cd209b; CDSIGN; CIRE; DC-SIGN; DC-SIGN1; DC-SIGNR1; Dcsign; mSIGNR1; OtB7; SIGN-R1; SIGNR1; SIGNR5
UniProt ID: (Mouse) Q91ZX1, (Mouse) Q8CJ91
Entrez Gene ID: (Mouse) 170786, (Mouse) 69165
endocytosis
regulation of gene expression
regulation of blood coagulation
regulation of T cell proliferation
viral entry into host cell
detection of yeast
phagocytosis, recognition
detection of bacterium
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of phagocytosis
