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SIRT6 Antibody (PA5-13225) in IHC (P)
Immunohistochemistry analysis of SIRT6 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with SIRT6 polyclonal antibody (Product # PA5-13225) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
产品信息
PA5-13225
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 290-319 amino acids from the C-terminal region of human SIRT6
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2254713
靶标信息
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hSIRT6; mSIRT6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2; SIR2 like 6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
基因别名: 2810449N18Rik; AI043036; SIR2L6; SIRT6
UniProt ID: (Human) Q8N6T7, (Mouse) P59941
Entrez Gene ID: (Human) 51548, (Mouse) 50721
chromatin binding
transcription corepressor activity
NAD+ ADP-ribosyltransferase activity
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD+ binding
histone deacetylase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
protein deacetylase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
metal ion binding
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
post-embryonic cardiac muscle cell growth involved in heart morphogenesis
base-excision repair
protein ADP-ribosylation
negative regulation of cell proliferation
regulation of double-strand break repair via homologous recombination
protein destabilization
response to nutrient levels
glucose homeostasis
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
negative regulation of glucose import
positive regulation of fibroblast proliferation
histone H3-K9 modification
histone H3-K9 deacetylation
positive regulation of stem cell proliferation
