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SIX3 Antibody (PA5-147534) in ICC/IF
Immunofluorescent staining of SIX3 in human cell line SH-SY5Y shows localization to nucleoplasm. Samples were probed using a SIX3 Polyclonal Antibody (Product # PA5-66970).
产品信息
PA5-147534
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human SIX3
偶联物
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
0
产品详细信息
Immunogen sequence: KNRLQHQAIGP SGMRSLAEPG CPTHGSAESP STAASPTTSV SSLTERADTG TSILSVTSSD S
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Homeobox protein SIX3; Sine oculis homeobox homolog 3; sine oculis homeobox-like protein 3
基因别名: HPE2; SIX3
UniProt ID: (Human) O95343
Entrez Gene ID: (Human) 6496
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription corepressor binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
histone deacetylase binding
homeodomain transcription factor
protein import into nucleus, translocation
eye development
epithelial cell maturation
lens development in camera-type eye
optic vesicle morphogenesis
transcription from RNA polymerase II promoter
brain development
visual perception
proximal/distal axis specification
neuroblast differentiation
telencephalon development
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
cell proliferation in forebrain
telencephalon regionalization
pituitary gland development
negative regulation of Wnt signaling pathway
regulation of cell proliferation
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
circadian behavior
lens induction in camera-type eye
regulation of neural retina development
lens fiber cell differentiation
neuroblast migration
regulation of cell cycle phase transition
regulation of neuroblast proliferation
apoptotic process involved in development
lens fiber cell apoptotic process
regulation of neural precursor cell proliferation
