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产品信息
PA5-75220
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 201-250 of Human Six3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2718948
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Two of these family members Six3 and Six6 (also designated Optx2 and Six9) are required for the specification and proliferation of the eye field in vertebrates, and, therefore, are the vertebrate homologues most closely related to the Drosophila sine oculis protein, which has an essential role in controlling compound eye development. Six3 and Six6 expression largely overlap during development of specific tissues, such as retina, hypothalamus, and pituitary. Deletion of Six3 may be associated with HPE2 disorder, a common, severe malformation of the brain that results from incomplete cleavage of the forebrain during early embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Homeobox protein SIX3; Homeobox protein SIX6; Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 3; Sine oculis homeobox homolog 6; sine oculis homeobox protein 6; sine oculis homeobox-like protein 3; sine oculis homeobox-like protein 6; sine oculis-related homeobox 3 homolog; sine oculis-related homeobox 6 homolog; Six9 protein
基因别名: E130112M24Rik; HPE2; MCOPCT2; ODRMD; OPTX2; SIX3; Six3a; Six3alpha; Six3b; Six3beta; SIX6; SIX9
UniProt ID: (Human) O95343, (Human) O95475, (Mouse) Q62233, (Mouse) Q9QZ28
Entrez Gene ID: (Human) 6496, (Human) 4990, (Mouse) 20473, (Rat) 78974, (Mouse) 20476, (Rat) 314221
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription corepressor binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
histone deacetylase binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
receptor binding
sequence-specific DNA binding
homeodomain transcription factor
protein import into nucleus, translocation
eye development
epithelial cell maturation
lens development in camera-type eye
optic vesicle morphogenesis
transcription from RNA polymerase II promoter
brain development
visual perception
proximal/distal axis specification
neuroblast differentiation
telencephalon development
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
cell proliferation in forebrain
telencephalon regionalization
pituitary gland development
negative regulation of Wnt signaling pathway
regulation of cell proliferation
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
circadian behavior
lens induction in camera-type eye
regulation of neural retina development
lens fiber cell differentiation
neuroblast migration
regulation of cell cycle phase transition
regulation of neuroblast proliferation
apoptotic process involved in development
lens fiber cell apoptotic process
regulation of neural precursor cell proliferation
organ morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
protein import into nucleus
multicellular organism development
diencephalon development
camera-type eye development
