Invitrogen

SLC39A4 Polyclonal Antibody

SLC39A4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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SLC39A4 Antibody (PA5-47915) in IHC (F)

Immunohistochemical analysis of SLC39A4 in immersion fixed frozen sections of adult mouse small intestine. Samples were incubated with SLC39A4 polyclonal antibody (Product # PA5-47915) using a dilution of 10 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to intestinal epithelial ce... View More

SLC39A4 Antibody in Flow Cytometry (Flow)

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产品信息

PA5-47915

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

免疫组化（冰冻） (IHC (F))

5-15 µg/mL

流式细胞分析 (Flow)

2.5 µg per million cells

产品规格

种属反应

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Mouse myeloma cell line NS0-derived recombinant mouse SLC39A4 Met1-Tyr337

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2607121

产品详细信息

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

靶标信息

The zinc transporter ZIP4, also known as SLC39A4, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP4 was initially identified as zinc-uptake transporter in the intestine and as a candidate gene for acrodermatitis enteropathica (AE), a rare inherited defect in the absorption of dietary zinc. Similar to other ZIP family members, aberrant expression of ZIP4 has been linked to cancer, specifically the progression and aggressiveness of pancreatic cancer. ZIP4 expression has also been shown to be activated in hepatocellular carcinomas, acting to repress apoptosis, enhance cell cycle and increase migration, suggesting ZIP4 may play a role in multiple types of cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。