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SLC6A11 Antibody (PA5-104150) in ICC/IF
Immunofluorescent analysis of SLC6A11 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SLC6A11 polyclonal antibody (Product # PA5-104150) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-104150
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SLC6A11(Accession P48066), corresponding to amino acid residues L406-T456.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853478
产品详细信息
Antibody detects endogenous levels of total SLC6A11.
靶标信息
Slc6a11 encode GABA transporters that are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) and mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters have been identified and localized to neurons and glia. The protein encoded by the Slc6a11 gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in the Slc6a11 gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for the Slc6a11 gene. Diseases associated with SLC6A11 include Tricuspid Valve Stenosis and Pulmonary Valve Insufficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA transporter 3; GABA transporter GAT-3; gamma-aminobutyric acid (GABA-A) transporter 4; GAT-3; GAT-4; Sodium- and chloride-dependent GABA transporter 3; Sodium- and chloride-dependent GABA transporter 4; solute carrier family 6 (neurotransmitter transporter), member 11; solute carrier family 6 (neurotransmitter transporter, GABA), member 11; Solute carrier family 6 member 11
基因别名: D930045G19Rik; E130202I16Rik; GABT3; Gabt4; GAT-3; Gat-4; Gat-b; GAT3; GAT4; SLC6A11
UniProt ID: (Human) P48066, (Rat) P31647, (Mouse) P31650
Entrez Gene ID: (Human) 6538, (Rat) 79213, (Mouse) 243616
