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SNRPA1 (U2 snRNP-A) is located in gene map locus 15q26. 3 and is a 28 kDa protein, isa specific component of U2 snRNP particle and consists of a unique N-terminal leucine-rich region and an extremely hydrophobic RNA-binding C-terminal region. It lacks segments homologous to RNP1 and RNP2, commonA. A motifs found in several RNA-binding proteins. It associates with U2 snRNP and participates in transcription and pre-mRNA splicing. It might play an important role in cell division and proliferation. Patients with connective tissue disorders often produce autoantibodies against snRNP particles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: U2 small nuclear ribonucleoprotein A'; U2 small nuclear ribonucleoprotein polypeptide A'; U2 snRNP A'; U2 snRNP-A'
基因别名: 1500015N06Rik; Lea1; SNRPA1
UniProt ID: (Human) P09661, (Mouse) P57784
Entrez Gene ID: (Human) 6627, (Mouse) 68981, (Rat) 100361269
分子生物学功能: RNA splicing factor