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SON Antibody (PA5-115947) in ICC/IF
Immunocytochemistry analysis of SON in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115947) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115947
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SON(Accession P18583), corresponding to amino acid residues K1804-S1854.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900581
产品详细信息
Antibody detects endogenous levels of total SON.
靶标信息
The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BASS1; Bax antagonist selected in Saccharomyces 1; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; Protein SON; Son cell proliferation protein; SON DNA-binding protein; SON3
基因别名: 2900011L12Rik; AA409051; AU067731; BASS1; C21orf50; C81487; DBP-5; DBP5; HSPC310; HSPC312; KIAA1019; mKIAA1019; NREBP; SON; SON3
UniProt ID: (Human) P18583, (Mouse) Q9QX47
Entrez Gene ID: (Human) 6651, (Rat) 304092, (Mouse) 20658
microtubule cytoskeleton organization
mitotic cytokinesis
mRNA processing
RNA splicing
negative regulation of apoptotic process
regulation of mRNA splicing, via spliceosome
regulation of cell cycle
regulation of RNA splicing
cytokinesis
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
