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产品信息
PA5-20617
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Hamster,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 20 amino acid peptide near the center of the human Spred1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155784
产品详细信息
A suggested positive control is mouse brain tissue lysate.
PA5-20617 can be used with blocking peptide PEP-0737.
靶标信息
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: protein phosphatase 1, regulatory subunit 147; Spred-1; sprouty protein with EVH-1 domain 1, related sequence; sprouty related, EVH1 domain containing 1; sprouty-related protein 1 with EVH-1 domain; sprouty-related, EVH1 domain containing 1; Sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
基因别名: 5730461F13Rik; AL024345; AW047647; hSpred1; NFLS; PPP1R147; spred-1; SPRED1
UniProt ID: (Human) Q7Z699, (Mouse) Q924S8
Entrez Gene ID: (Human) 161742, (Rat) 296072, (Mouse) 114715
MAPK cascade
inactivation of MAPK activity
multicellular organism development
fibroblast growth factor receptor signaling pathway
negative regulation of peptidyl-threonine phosphorylation
negative regulation of phosphatase activity
positive regulation of DNA damage response, signal transduction by p53 class mediator
regulation of protein deacetylation
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction
