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Invitrogen
SPT5 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
PA5-56100
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647899
产品详细信息
Immunogen sequence: VGYSPMTPGA PSPGGYNPHT PGSGIEQNSS DWVTTDIQVK VRDTYLDTQV VGQTGVIRSV TGGMCSVYLK DSEKVVSISS EHLEPITPTK NNKVKVILGE DREATGVLLS IDGEDGIVRM DLDEQLKILN LRFL
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
靶标信息
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DRB sensitivity-inducing factor 160 kDa subunit; DRB sensitivity-inducing factor large subunit; DSIF large subunit; DSIF p160; hSPT5; suppressor of Ty 5 homolog; Tat-cotransactivator 1 protein; Tat-CT1 protein; Transcription elongation factor SPT5
基因别名: AL033283; AL033321; AU019549; SPT5; SPT5H; Supt5; SUPT5H; Tat-CT1
UniProt ID: (Human) O00267, (Mouse) O55201
Entrez Gene ID: (Human) 6829, (Mouse) 20924, (Rat) 308472
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
DNA-templated transcription, elongation
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
cell cycle
response to organic substance
positive regulation of macroautophagy
negative regulation of DNA-templated transcription, elongation
positive regulation of DNA-templated transcription, elongation
single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of transcription from RNA polymerase II promoter
positive regulation of viral transcription
negative regulation of mRNA polyadenylation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of DNA-templated transcription, elongation
