Invitrogen

SR-BI Polyclonal Antibody

SR-BI Antibody in Immunocytochemistry (ICC/IF)

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SR-BI Antibody (PA5-29789) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of SR-BI was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: SR-BI Polyclonal Antibody (Product # PA5-29789) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker. Blue: Hoechst 33342 staining.

SR-BI Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SR-BI Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-29789

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

流式细胞分析 (Flow)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein fragment corresponding to a region within amino acids 290 and 492 of Human SR-BI

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.12 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2547263

产品详细信息

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Rat liver.

Predicted reactivity: Mouse (83%), Pig (91%), Rabbit (87%), Bovine (86%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis.

Nature communications

Mutoh T,Shirai T,Ishii T,Shirota Y,Fujishima F,Takahashi F,Kakuta Y,Kanazawa Y,Masamune A,Saiki Y,Harigae H,Fujii H

Published figure using SR-BI polyclonal antibody (Product # PA5-29789) in Immunohistochemistry

Mon Mar 09 00:00:00 EDT 2020

Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis.

Nature communications

Mutoh T,Shirai T,Ishii T,Shirota Y,Fujishima F,Takahashi F,Kakuta Y,Kanazawa Y,Masamune A,Saiki Y,Harigae H,Fujii H

Published figure using SR-BI polyclonal antibody (Product # PA5-29789) in Immunohistochemistry

Mon Mar 09 00:00:00 EDT 2020

生物信息学

蛋白别名: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B1; SR-BI; SRB1

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基因别名: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI

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UniProt ID: (Human) Q8WTV0, (Rat) P97943, (Mouse) D3Z2V4

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Entrez Gene ID: (Human) 949, (Rat) 25073, (Mouse) 20778

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功能