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产品信息
PA5-75246
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 50-100 of Human SRY.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2718974
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: essential protein for sex determination in human males; HMG box transcription factor Sry1; HMG box transcription factor Sry3BI; sex determining region of Chr Y; sex determining region on Y; sex determining region Y protein; sex-determining region on Y; Sex-determining region Y protein; Testis determining locus; testis determining-Y; Testis-determining factor; testis-determining factor on Y
基因别名: SRXX1; SRXY1; SRY; Sry1; Sry3BI; SRYGENE; TDF; TDY
UniProt ID: (Human) Q05066, (Mouse) Q05738
Entrez Gene ID: (Human) 6736, (Mouse) 21674, (Rat) 25221
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
calmodulin binding
transcription factor binding
DNA binding, bending
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
sequence-specific DNA binding
HMG box transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
male gonad development
cell differentiation
male sex determination
positive regulation of transcription, DNA-templated
positive regulation of male gonad development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
sex determination
sex differentiation
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
