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STAT1 Antibody (PA1-41383) in IHC (P)
Immunohistochemical analysis of STAT1 in formalin-fixed paraffin-embedded tissue section of human lymph node. Samples were incubated in STAT1 polyclonal antibody (Product # PA1-41383) using a dilution of 1:200 followed by HRP labeled anti-rabbit secondary antibody and DAB reagent. Nuclei of cells were counter-stained with hematoxylin. Strong nuclear staining in germinal center and surrounding cells along wi... View More
产品信息
PA1-41383
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Mouse,
Non-human primate,
Pig
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide sequence corresponding to amino acids between 700 and 750 of human Stat1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2198291
产品详细信息
This antibody is predicted to react in chicken and rat samples based on sequence homology.
This sequence is 100% conserved between Stat1 alpha and Stat1 beta.
Suggested positive control: Hela whole cell extract, HeLa cell lysate.
靶标信息
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686B04100; OTTHUMP00000165046; OTTHUMP00000205845; Signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT-1; stat1 alpha; Transcription factor ISGF-3 components p91/p84
基因别名: 2010005J02Rik; AA408197; CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91
UniProt ID: (Human) P42224, (Pig) Q764M5
Entrez Gene ID: (Human) 6772, (Dog) 488449, (Pig) 396655, (Mouse) 20846
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
tumor necrosis factor receptor binding
protein binding
enzyme binding
nuclear hormone receptor binding
identical protein binding
protein homodimerization activity
cadherin binding involved in cell-cell adhesion
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
CCR5 chemokine receptor binding
sequence-specific DNA binding
protein phosphatase 2A binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
negative regulation of endothelial cell proliferation
positive regulation of mesenchymal cell proliferation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
transcription, DNA-templated
apoptotic process
JAK-STAT cascade
blood circulation
macrophage derived foam cell differentiation
negative regulation of angiogenesis
tumor necrosis factor-mediated signaling pathway
response to cytokine
response to interferon-beta
cellular response to interferon-beta
regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to peptide hormone
endothelial cell migration
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation by virus of viral protein levels in host cell
positive regulation of smooth muscle cell proliferation
response to cAMP
defense response to virus
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
renal tubule development
cellular response to organic cyclic compound
metanephric mesenchymal cell proliferation involved in metanephros development
metanephric mesenchymal cell differentiation
negative regulation of metanephric nephron tubule epithelial cell differentiation
cell-cell adhesion
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to nutrient
positive regulation of cell proliferation
positive regulation of interferon-alpha production
cellular response to insulin stimulus
positive regulation of erythrocyte differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
signal transduction
response to mechanical stimulus
response to bacterium
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
negative regulation of macrophage fusion
response to drug
response to exogenous dsRNA
cellular response to lipopolysaccharide
