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产品信息
PA5-121034
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 18-247 of human STC1 (NP_003146.1).
偶联物
形式
Liquid
浓度
2.55 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914606
产品详细信息
Positive test controls include: Mouse lung. The target is usually found in the following locations: Secreted.^M
^M
Immunogen sequence: THEAEQNDSV SPRKSRVAAQ NSAEVVRCLN SALQVGCGAF ACLENSTCDT DGMYDICKSF LYSAAKFDTQ GKAFVKESLK CIANGVTSKV FLAIRRCSTF QRMIAEVQEE CYSKLNVCSI AKRNPEAITE VVQLPNHFSN RYYNRLVRSL LECDEDTVST IRDSLMEKIG PNMASLFHIL QTDHCAQTHP RADFNRRRTN EPQKLKVLLR NLRGEEDSPS HIKRTSHESA
靶标信息
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Stanniocalcin-1; STC-1
基因别名: STC; STC1
UniProt ID: (Human) P52823, (Mouse) O55183, (Rat) P97574
Entrez Gene ID: (Human) 6781, (Mouse) 20855, (Rat) 81801
ossification
endothelial cell morphogenesis
growth plate cartilage axis specification
cellular calcium ion homeostasis
embryo implantation
negative regulation of endothelial cell migration
negative regulation of cell migration
response to vitamin D
chondrocyte proliferation
regulation of anion transport
decidualization
negative regulation of calcium ion transport
bone development
cellular response to cAMP
cellular response to glucocorticoid stimulus
cellular response to hypoxia
regulation of cardiac muscle cell contraction
positive regulation of calcium ion import
negative regulation of renal phosphate excretion
cellular monovalent inorganic anion homeostasis
response to organic cyclic compound
