Invitrogen

STING Polyclonal Antibody

图: 1 / 1

STING Antibody (PA5-70420) in WB

Western blot analysis of STING on rat spleen tissue lysate. The sample was probed with a STING polyclonal antibody (Product # PA5-70420) using a primary antibody dilution of 1.0 µg/mL.

Product Image Gallery

产品信息

PA5-70420

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

- -

产品规格

种属反应

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the C-terminal region of rat STING

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2689650

产品详细信息

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

靶标信息

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。