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STK36 Antibody (PA5-106734) in IHC (P)
Immunohistochemistry analysis of STK36 in rat testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with STK36 polyclonal antibody (Product # PA5-106734) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-106734
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human STK36(Accession Q9NRP7), corresponding to amino acid residues D386-A436.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854402
产品详细信息
Antibody detects endogenous levels of total STK36.
靶标信息
Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fused homolog; serine/threonine kinase 36 (fused homolog, Drosophila); Serine/threonine-protein kinase 36; STK36; testicular tissue protein Li 188
基因别名: 1700112N14Rik; B930045J24; FU; Fused; KIAA1278; mKIAA1278; STK36
UniProt ID: (Human) Q9NRP7, (Mouse) Q69ZM6
Entrez Gene ID: (Human) 27148, (Rat) 301516, (Mouse) 269209
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
transcription factor binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
epithelial cilium movement
protein phosphorylation
positive regulation of hh target transcription factor activity
brain development
post-embryonic development
cilium assembly
positive regulation of smoothened signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
multicellular organism development
phosphorylation
cell projection organization
