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SULF1 Antibody (PA5-115984) in ICC/IF
Immunocytochemistry analysis of SULF1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115984) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115984
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SULF1(Accession Q8IWU6), corresponding to amino acid residues L412-Q462.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900618
产品详细信息
Antibody detects endogenous levels of total Sulfatase 1.
靶标信息
Heparan sulfate proteoglycans act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arylsulfatase; Extracellular sulfatase Sulf-1; FLJ30905; FLJ38022; FLJ41750; hSulf-1; MSulf-1; N-acetylglucosamine-6-sulfatase; RSulfFP1; Sulfatase FP
基因别名: AI467640; AW121680; KIAA1077; mKIAA1077; SULF-1; SULF1
UniProt ID: (Human) Q8IWU6, (Mouse) Q8K007, (Rat) Q8VI60
Entrez Gene ID: (Human) 23213, (Mouse) 240725, (Rat) 171396
kidney development
negative regulation of endothelial cell proliferation
chondrocyte development
glomerular filtration
apoptotic process
positive regulation of vascular endothelial growth factor production
esophagus smooth muscle contraction
negative regulation of angiogenesis
positive regulation of Wnt signaling pathway
heparan sulfate proteoglycan metabolic process
negative regulation of cell migration
positive regulation of BMP signaling pathway
glomerular basement membrane development
glial cell-derived neurotrophic factor receptor signaling pathway
regulation of fibroblast growth factor receptor signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
embryonic skeletal system development
cartilage development
bone development
innervation
negative regulation of prostatic bud formation
sulfur compound metabolic process
metabolic process
cartilage condensation
cell adhesion
limb joint morphogenesis
positive regulation of smooth muscle cell proliferation
