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Application
FIGURE: 1 / 6
SULT2A1 Antibody (PA5-89604) in IHC (P)
Immunohistochemistry analysis of SULT2A1 in paraffin-embedded human gastric cancer. Samples were incubated with SULT2A1 Polyclonal antibody (Product # PA5-89604) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-89604
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human SULT2A1 (NP_0031582)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.26 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805681
Product Specific Information
Immunogen sequence: MSDDFLWFEG IAFPTMGFRS ETLRKVRDEF VIRDEDVIIL TYPKSGTNWL AEILCLMHSK GDAKWIQSVP IWERSPWVES EIGYTALSET ESPRLFSSHL PIQLFPKSFF SSKAKVIYLM RNPRDVLVSG YFFWKNMKFI KKPKS; Positive Samples: Mouse skeletal muscle; Cellular Location: Cytoplasm
Target Information
SULT1 sulfotransferases exhibit N-sulfating activities of carcinogenic heterocyclic amines, and are selective toward phenols, whereas SULT2 enzymes prefer hydroxysteroids and SULT3 family members are selective for N-substituted aryl and alicyclic compounds. SULT2A1 catalyzes the sulfonation of procarcinogen xenobiotics, hydroxysteroids and bile acids, and is highly expressed in adrenal and liver tissues. SULT2A1 plays a role in hepatic cholesterol homeostasis. SULT2B1 consists of two isoforms, SULT2B1a and SULT2B1b, which are transcribed from the same gene by alternative splicing of their first exons. Both isoforms are highly selective for the sulphation of 3b-hydroxysteroids such as pregnenolone, epiandrosterone, DHEA and androstenediol. SULT2B1b is expressed in prostate, skin, placenta and lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alcohol sulfotransferase; alcohol/hydroxysteroid sulfotransferase; Bile salt sulfotransferase; Bile salt sulfotransferase 1; bile-salt sulfotranasferase 2A1; bile-salt sulfotransferase 2A1; Dehydroepiandrosterone sulfotransferase; DHEA-ST; HST; Hydroxysteroid Sulfotransferase; hydroxysteroid sulfotransferase a; ST; ST-20; ST2; ST2A1; Sulfotransferase 2A1; sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1; sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; sulfotransferase hydroxysteroid gene 2; sulfotransferase, DHEA preferring; sulfotransferase, hydroxysteroid preferring 1; sulfotransferase, hydroxysteroid preferring 2; SULT2A3
Gene Aliases: DHEA-ST; DHEAS; HST; hSTa; mSTa1; Smp-2; ST2; ST2A1; ST2A3; STa; Sta1; STD; Sth1; Sth2; SULT2A1
UniProt ID: (Human) Q06520, (Mouse) P52843, (Rat) P15709
Entrez Gene ID: (Human) 6822, (Mouse) 20859, (Rat) 24912
aryl sulfotransferase activity
estrone sulfotransferase activity
protein binding
sulfotransferase activity
bile-salt sulfotransferase activity
steroid sulfotransferase activity
alcohol sulfotransferase activity
drug binding
transferase activity
3'-phosphoadenosine 5'-phosphosulfate binding
transferase
digestion
steroid metabolic process
bile acid catabolic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
sulfation
lipid metabolic process
aging
metabolic process
response to activity
response to insecticide
drug metabolic process
response to nutrient levels
cellular response to vitamin D
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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