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Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:7556078, PubMed:20947765, PubMed:34413231). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:7556078, PubMed:20947765). SUP45/eRF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:7556078, PubMed:20947765, PubMed:34413231). Following GTP hydrolysis by SUP35/eRF3, SUP35/eRF3 dissociates, permitting SUP45/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:7556078, PubMed:20947765, PubMed:34413231).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor 1; Omnipotent suppressor protein 1; SAL4; SUP1
基因别名: SAL4; SUP1; SUP45; SUP47; YBR1120; YBR143C
UniProt ID: (Baker's yeast) P12385
Entrez Gene ID: (Baker's yeast) 852440
分子生物学功能:
translation factor
translation release factor
translational protein