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Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1
基因别名: H3-K9-HMTase 1; KMT1A; MG44; SUV39H; SUV39H1
UniProt ID: (Human) O43463
Entrez Gene ID: (Human) 6839
分子生物学功能:
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme