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SUV39H1 Antibody (PA5-87177) in ICC/IF
Immunofluorescence analysis of Histone-lysine N-methyltransferase SUV39H1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with SUV39H1 Polyclonal Antibody (Product # PA5-87177) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa ... View More
产品信息
PA5-87177
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of human SUV39H1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803927
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; Suv39h histone methyltransferase
基因别名: AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1; KMT1A; MG44; mIS6; RGD1565028; SUV39H; SUV39H1
UniProt ID: (Human) Q53G60, (Mouse) O54864
Entrez Gene ID: (Human) 6839, (Mouse) 20937, (Rat) 302553
transcription regulatory region sequence-specific DNA binding
chromatin binding
protein binding
zinc ion binding
S-adenosylmethionine-dependent methyltransferase activity
histone-lysine N-methyltransferase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K9 specific)
protein N-terminus binding
RNA polymerase II regulatory region sequence-specific DNA binding
methyltransferase activity
protein methyltransferase activity
transferase activity
metal ion binding
molecular_function
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
chromatin organization
transcription, DNA-templated
rRNA processing
cellular response to DNA damage stimulus
cell cycle
viral process
cell differentiation
histone H3-K9 dimethylation
histone H3-K9 trimethylation
negative regulation of circadian rhythm
negative regulation of transcription, DNA-templated
rhythmic process
cellular response to hypoxia
DNA packaging
chromatin silencing
regulation of transcription, DNA-templated
protein methylation
chromatin modification
methylation
histone lysine methylation
histone H3-K9 methylation
biological_process
