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SUV420H2 Chimeric Antibody (MA5-48341) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of SUV420H2 in HEK293 cells using SUV420H2 Chimeric Monoclonal Antibody (Product # MA5-48341). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with SUV420H2 Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining. The nuclear stain is DAPI (blue) and the actin ... View More
产品信息
MA5-48341
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RAB-C409
抗原
This antibody was obtained by recombinant antibody (rAb) phage display recognizing SUV420H2 protein under non-denaturing conditions.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074783
产品详细信息
Specificity: This antibody recognizes KMT5C (Histone-lysine N-methyltransferase KMT5C). It binds to a folded domain, amino acids 2-248. KMT5C is a histone methyltransferase that regulates transcription and maintenance of genome integrity.
靶标信息
SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H4]-lysine20 N-methyltransferase KMT5B; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; Histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; lysine (K)-specific methyltransferase 5C; Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C; Su(var)4-20 homolog 2; Suppressor of variegation 4-20 homolog 2; suv4-20h2
基因别名: KMT5C; PP7130; SUV420H2
UniProt ID: (Human) Q86Y97
Entrez Gene ID: (Human) 84787
