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SUZ12 Antibody (MA5-42458) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of SUZ12 in SKOV-3 cells (green) using SUZ12 Recombinant Monoclonal Antibody (Product # MA5-42458). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
产品信息
MA5-42458
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JJ09-04
抗原
Recombinant protein within human suz12 aa 1-150
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2911599
产品详细信息
Positive Control: SW480, MCF-7, Hela, SKOV-3.
Subcellular Location: Nucleus.
靶标信息
SUZ12 (polycomb protein SUZ12) is a zinc finger gene and has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. SUZ12 is also a component of the PRC2/EED-EZH2 complex which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3 leading to transcriptional repression of the affected target gene. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog; SUZ12 polycomb repressive complex 2 subunit
基因别名: 2610028O16Rik; AI195385; AU016842; AW536442; CHET9; D11Ertd530e; JJAZ1; KIAA0160; mKIAA0160; SUZ12
UniProt ID: (Human) Q15022, (Mouse) Q80U70
Entrez Gene ID: (Human) 23512, (Mouse) 52615, (Rat) 688041
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of cell proliferation
histone methylation
histone ubiquitination
negative regulation of cell differentiation
negative regulation of gene expression, epigenetic
regulation of transcription, DNA-templated
chromatin modification
negative regulation of chemokine production
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of epithelial cell proliferation
histone H3-K27 trimethylation
spinal cord development
response to retinoic acid
