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Sequence of this protein is as follows: MSPLRPLLLA LALASVPCAQ GACPASADLK HSDGTRTCAK LYDKSDPYYE NCCGGAELSL ESGADLPYLP SNWANTASSL VVAPRCELTV WSRQGKAGKT HKFSAGTYPR LEEYRRGILG DWSNAISALY CRCS
Syncollin is a 134 amino acid, small peripheral membrane protein abundantly expressed in pancreatic acinar cells and is tightly associated with the lumenal side of the zymogen granule membrane. It contains intrachain disulfide bonds. Syncollin is also known to associate with lipid rafts in a cholesterol-dependent manner. In pancreatic acinar cells, syncollin helps in exocytosis and also plays a role in maturation and/or concentration of zymogens in zymogen granules. Reports suggest that syncollin may also have a pore-forming activity on membranes and regulate exocytosis insome exocrine tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ27441; insulin synthesis associated 1; Insulin synthesis-associated protein 1; Syncollin
基因别名: INSSA1; SYCN; SYL
UniProt ID: (Human) Q0VAF6
Entrez Gene ID: (Human) 342898