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Sirt6 Antibody (A302-452A) in WB
Detection of human Sirt6 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-Sirt6 antibody A302-452A used for WB at 0.4 µg/ml (A) and 1 µg/ml (B) and used for IP at 3 µg/mg lysate. Sirt6 was also immunoprecipitated by rabbit anti-Sirt6 antibody A302-451A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 3... View More
产品信息
A302-452A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 305 and 355 of Human sirtuin (silent mating type information regulation 2 homolog) 6.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hSIRT6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2; SIR2 like 6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
基因别名: SIR2L6; SIRT6
UniProt ID: (Human) Q8N6T7
Entrez Gene ID: (Human) 51548
chromatin binding
transcription corepressor activity
NAD+ ADP-ribosyltransferase activity
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD+ binding
post-embryonic cardiac muscle cell growth involved in heart morphogenesis
base-excision repair
protein ADP-ribosylation
negative regulation of cell proliferation
regulation of double-strand break repair via homologous recombination
protein destabilization
response to nutrient levels
glucose homeostasis
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
negative regulation of glucose import
positive regulation of fibroblast proliferation
histone H3-K9 modification
histone H3-K9 deacetylation
positive regulation of stem cell proliferation
