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产品信息
PA5-83005
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2790161
产品详细信息
Immunogen sequence: MEKVNILTDK SYEDPTNIQG KYQKHQSLEA EVQTKSRLMS ELEKTREERF TMGHSAHEET KAHIEELRHL WDLLLELTLE KGDQLLRALK FQQYVQECA
靶标信息
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
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生物信息学
蛋白别名: alpha-I spectrin; elliptocytosis 2; Erythroid alpha-spectrin; mutant alpha spectrin; spectrin alpha chain, erythrocyte; Spectrin alpha chain, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
基因别名: EL2; HPP; HS3; SPH3; SPTA; SPTA1
UniProt ID: (Human) P02549
Entrez Gene ID: (Human) 6708
MAPK cascade
lymphocyte homeostasis
porphyrin-containing compound biosynthetic process
ER to Golgi vesicle-mediated transport
plasma membrane organization
actin filament organization
axon guidance
regulation of cell shape
hemopoiesis
positive regulation of protein binding
positive regulation of T cell proliferation
positive regulation of GTPase activity
actin filament capping
