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Substance P Antibody (PA5-106934) in IHC (P)
Immunohistochemistry analysis of Substance P in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Substance P polyclonal antibody (Product # PA5-106934) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-106934
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TAC1(Accession P20366), corresponding to amino acid residues D38-Y88.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854598
产品详细信息
Antibody detects endogenous levels of total Substance P.
靶标信息
Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC26719; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide gamma; neuropeptide K; PPT; precursor 1; preprotachykinin; preprotachykinin A; protachykinin; Protachykinin-1; RAT TAC; substance K; substance P; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
基因别名: 4930528L02Rik; Hs.2563; NK-1; NK1; NK2; NKA; NKNA; NPK; PPT-A; Ppt5fl; PPTA; PPTA3; RATPPTA3; SP; TAC; TAC1; TAC2
UniProt ID: (Human) P20366, (Rat) P06767, (Mouse) P41539
Entrez Gene ID: (Human) 6863, (Rat) 24806, (Mouse) 21333
positive regulation of acute inflammatory response
inflammatory response
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
neuropeptide signaling pathway
cell-cell signaling
chemical synaptic transmission
insemination
long-term memory
regulation of blood pressure
associative learning
detection of abiotic stimulus
response to hormone
negative regulation of heart rate
positive regulation of epithelial cell migration
sensory perception of pain
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
positive regulation of renal sodium excretion
response to morphine
positive regulation of action potential
positive regulation of ossification
positive regulation of saliva secretion
response to pain
positive regulation of lymphocyte proliferation
positive regulation of stress fiber assembly
cellular response to nerve growth factor stimulus
positive regulation of corticosterone secretion
