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产品信息
PA5-54567
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2648140
产品详细信息
Immunogen sequence: GMEMDYEEVI RLLEAKITEL KAQLADYSDQ NKESVQDLKK RIMVLDCQLR KSEMARKTFE ASTEKLLHFV EAIQEVFSDN STPLSNLSER RAVLASQT
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
靶标信息
STXBP4 plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. STXBP4 inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. STXBP4 may also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.
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生物信息学
蛋白别名: FLJ16496; MGC149829; MGC50337; STX4-interacting protein; syntaxin 4 interacting protein; Syntaxin 4-interacting protein; Syntaxin-binding protein 4
基因别名: STXBP4; Synip
UniProt ID: (Human) Q6ZWJ1
Entrez Gene ID: (Human) 252983
protein targeting
cellular response to DNA damage stimulus
insulin receptor signaling pathway
positive regulation of keratinocyte proliferation
glucose transport
protein stabilization
regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of cell cycle G1/S phase transition
