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产品信息
PA1-9108
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C terminus amino acids SASDGSVCVLDLRK (aa 564-577).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2199908
产品详细信息
This antibody is expected to recognize the human protein TBL1XR1 (NP_078941) as well as TBL1X. Variants (NP_005638.1; NP_001132938.1) encode isoform a (TBL1X) and variants (NP_001132939.1; NP_001132940.1 ) encode isoform b (TBL1X).
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
靶标信息
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
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生物信息学
蛋白别名: F-box-like/WD repeat-containing protein TBL1X; F-box-like/WD repeat-containing protein TBL1XR1; nuclear receptor co-repressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; SMAP55; TBL1-related protein 1; Transducin beta-like 1X-related protein 1; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
基因别名: C21; DC42; EBI; IRA1; MRD41; SMAP55; TBL1; TBL1X; TBL1XR1; TBLR1
UniProt ID: (Human) O60907, (Human) Q9BZK7
Entrez Gene ID: (Human) 6907, (Human) 79718
negative regulation of transcription from RNA polymerase II promoter
response to dietary excess
transcription, DNA-templated
lipid catabolic process
histone deacetylation
regulation of cAMP metabolic process
multicellular organism growth
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
white fat cell differentiation
canonical Wnt signaling pathway
fat pad development
regulation of triglyceride metabolic process
proteolysis
sensory perception of sound
