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Invitrogen
TCF2 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
图: 1 / 5
TCF2 Antibody (720259) in ICC/IF
For immunofluorescence analysis, Hep G2 cells were fixed and permeabilized for detection of endogenous HNF1b using HNF1b Rabbit Polyclonal Antibody (Product# 720259, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of HNF1b protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c) repr... View More
产品信息
720259
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptides corresponding to Human HNF1b (aa 511:528, 191:208)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633221
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Horse and Cat.
靶标信息
Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF-1-beta; HNF-1B; HNF1 beta A; Homeoprotein LFB3; TCF-2; Transcription factor 2; Transcription factor 2 hepatic; Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor; Transcription factor 2, hepatic; Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor; Variant hepatic nuclear factor 1; vHNF1
基因别名: FJHN; HNF-1-beta; HNF-1B; HNF-1Beta; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
UniProt ID: (Human) P35680, (Rat) P23899, (Mouse) P27889
Entrez Gene ID: (Human) 6928, (Rat) 25640, (Mouse) 21410
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter proximal region DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
protein complex binding
protein homodimerization activity
protein heterodimerization activity
DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate specification
kidney development
inner cell mass cell differentiation
transcription, DNA-templated
Notch signaling pathway
response to glucose
anterior/posterior pattern specification
response to organic cyclic compound
insulin secretion
regulation of Wnt signaling pathway
hindbrain development
circadian regulation of gene expression
regulation of pronephros size
pronephric nephron tubule development
response to drug
regulation of endodermal cell fate specification
positive regulation of transcription, DNA-templated
embryonic digestive tract morphogenesis
branching morphogenesis of an epithelial tube
pronephros development
epithelial cell proliferation
positive regulation of transcription initiation from RNA polymerase II promoter
ureteric bud elongation
hepatoblast differentiation
negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
protein-DNA complex assembly
hepatocyte differentiation
regulation of branch elongation involved in ureteric bud branching
mesonephric duct formation
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
liver development
transcription from RNA polymerase II promoter
endoderm development
response to carbohydrate
positive regulation of gene expression
endocrine pancreas development
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
embryonic morphogenesis
genitalia development
epithelium development
kidney morphogenesis
mesonephric tubule development
nephric duct development
mesonephric duct development
nephric duct formation
endoderm formation
regulation of transcription, DNA-templated
