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Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Rhesus Monkey (93%), Chimpanzee (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Tyr-DNA phosphodiesterase 1; Tyrosyl-DNA phosphodiesterase 1
基因别名: TDP1
UniProt ID: (Human) Q9NUW8
Entrez Gene ID: (Human) 55775