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产品信息
MA5-16034
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Cynomolgus monkey,
Human,
Mouse
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
2C4
抗原
Full-length recombinant hTERT from insect cells.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
IgM
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153210
产品详细信息
Suggested positive control: 293T whole cell lysates, HeLa whole cell lysates, antigen standard for TERT (transient overexpression lysate).
靶标信息
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HEST2; hTERT; Telomerase catalytic subunit; Telomerase reverse transcriptase; telomerase reverse transcriptase beta; Telomerase-associated protein 2; tert {ECO:0000312|RGD:70494}; TP2
基因别名: CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TERT; TP2; TR; TRT
UniProt ID: (Human) O14746, (Rat) Q673L6, (Mouse) O70372
Entrez Gene ID: (Human) 7015, (Rat) 301965, (Mouse) 21752
tRNA binding
transcription coactivator binding
DNA binding
telomerase activity
telomerase RNA reverse transcriptase activity
RNA binding
RNA-directed DNA polymerase activity
RNA-directed RNA polymerase activity
protein binding
nucleotidyltransferase activity
telomeric DNA binding
protein homodimerization activity
metal ion binding
telomerase RNA binding
transferase activity
DNA metabolism protein
nucleic acid metabolism protein
telomere maintenance
transcription, RNA-templated
RNA-dependent DNA biosynthetic process
telomere maintenance via telomerase
mitochondrion organization
negative regulation of gene expression
DNA strand elongation
positive regulation of Wnt signaling pathway
production of siRNA involved in RNA interference
regulation of protein stability
positive regulation of protein binding
RNA biosynthetic process
positive regulation of hair cycle
positive regulation of nitric-oxide synthase activity
establishment of protein localization to telomere
cellular response to hypoxia
DNA biosynthetic process
replicative senescence
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of production of siRNA involved in RNA interference
positive regulation of protein localization to nucleolus
beta-catenin-TCF complex assembly
positive regulation of stem cell proliferation
negative regulation of cellular senescence
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
obsolete age-dependent telomere shortening
biological_process
telomere formation via telomerase
