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TET1 Antibody (PA5-49432) in WB
Western blot analysis of TET1 in F9 whole cell lysate. Samples were incubated with TET1 polyclonal antibody (Product # PA5-49432) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 219 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
产品信息
PA5-49432
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1845-1879 amino acids from the C-terminal region of mouse Tet1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2634886
靶标信息
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CXXC finger 6; CXXC-type zinc finger protein 6; Methylcytosine dioxygenase TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein homolog; tet oncogene 1
基因别名: 2510010B09Rik; AA517754; BB001228; Cxxc6; D10Ertd17e; Kiaa1676; LCX; mKIAA1676; Tet1
UniProt ID: (Mouse) Q3URK3
Entrez Gene ID: (Mouse) 52463
inner cell mass cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein O-linked glycosylation
chromatin modification
stem cell population maintenance
regulation of DNA methylation
positive regulation of transcription from RNA polymerase II promoter
oxidation-reduction process
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
regulation of genetic imprinting
