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TGF beta-3 Antibody (MA5-23812) in IHC (P)
Immunohistochemical analysis of TGF beta-3 in immersion fixed paraffin-embedded sections of human breast cancer tissue. Samples were incubated in TGF beta-3 monoclonal antibody (Product # MA5-23812) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cy... View More
产品信息
MA5-23812
产品规格
种属反应
Human,
Many,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
20724
抗原
Sf 21-derived recombinant human TGF-beta 3 Ala301-Ser412 (Tyr340Phe)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609528
产品详细信息
In Western blots, less than 25% cross-reactivity with recombinant human (rh) TGF- beta 1.2 and rhTGF-beta 2 is observed, and less than 2% cross-reactivity with recombinant amphibian TGF-beta 5 and recombinant human TGF-beta 1 is observed. This antibody neutralizes the biological activity of TGF-beta 3 but not TGF-beta 1, TGF-beta 2, or TGF-beta 5.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3
基因别名: ARVD; ARVD1; LDS5; RNHF; TGF-B3; TGF-beta3; Tgfb-3; TGFB3
UniProt ID: (Human) P10600, (Rat) Q07258
Entrez Gene ID: (Human) 7043, (Rat) 25717, (Mouse) 21809
type II transforming growth factor beta receptor binding
cytokine activity
protein binding
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
identical protein binding
protein heterodimerization activity
transforming growth factor beta binding
transforming growth factor beta receptor binding
growth factor
activation of MAPK activity
response to hypoxia
in utero embryonic development
platelet degranulation
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
salivary gland morphogenesis
female pregnancy
aging
negative regulation of DNA replication
negative regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of macrophage cytokine production
cell growth
positive regulation of bone mineralization
negative regulation of transforming growth factor beta receptor signaling pathway
mammary gland development
response to progesterone
positive regulation of collagen biosynthetic process
response to laminar fluid shear stress
wound healing
regulation of cell proliferation
odontogenesis
uterine wall breakdown
regulation of apoptotic process
positive regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron apoptotic process
response to estrogen
ossification involved in bone remodeling
cell-cell junction organization
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
digestive tract development
embryonic neurocranium morphogenesis
inner ear development
positive regulation of protein secretion
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
positive regulation of cell division
palate development
face morphogenesis
frontal suture morphogenesis
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
detection of hypoxia
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of occluding junction disassembly
organ morphogenesis
lung development
regulation of epithelial cell differentiation
regulation of endothelial cell differentiation
cell development
regulation of epithelial cell proliferation
cellular response to growth factor stimulus
embryo development
growth
