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产品信息
PA5-20777
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the carboxy terminus of human THEM2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152906
产品详细信息
A suggested positive control is HepG2 cell lysate.
PA5-20777 can be used with blocking peptide PEP-0891.
靶标信息
THEM2, also known as ACOT13, belongs to the hotdog-fold superfamily and possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. THEM2 is highly expressed in several tissues such as heart, kidney, liver and brain and has been shown to be co-localized with beta-tubulin on microtubules. THEM2 interacts with StarD, a protein that plays a key role in fatty acid metabolism, and the addition of StarD to THEM2 increased its catalytic activity, suggesting that THEM2 plays a significant role in the metabolism of fatty acids. At least two isoforms of THEM2 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acyl-CoA thioesterase 13; Acyl-coenzyme A thioesterase 13; Hotdog-fold thioesterase superfamily member 2; hypothalamus protein HT012; Palmitoyl-CoA hydrolase; THEM2; Thioesterase superfamily member 2
基因别名: 0610006O17Rik; ACOT13; HT012; PNAS-27; THEM2
UniProt ID: (Human) Q9NPJ3, (Mouse) Q9CQR4
Entrez Gene ID: (Human) 55856, (Rat) 291135, (Mouse) 66834
acyl-CoA hydrolase activity
CoA hydrolase activity
hydrolase activity
2-oxoglutaryl-CoA thioesterase activity
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
3-isopropylbut-3-enoyl-CoA thioesterase activity
glutaryl-CoA hydrolase activity
esterase
hydrolase
metabolite interconversion enzyme
