Invitrogen

THRAP5 Polyclonal Antibody

THRAP5 Antibody in Immunohistochemistry (IHC)

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THRAP5 Antibody (PA5-40517) in IHC

Immunohistochemistry analysis of human brain tissue using an anti-THRAP5 polyclonal antibody (Product # PA5-40517).

THRAP5 Antibody in Western Blot, Immunohistochemistry (WB, IHC)

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产品信息

PA5-40517

应用

建议稀释比

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免疫印迹 (WB)

0.12 µg/mL

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免疫组化 (IHC)

5 µg/mL

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产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the C-terminal of human THRAP5 (aa 749-798).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2576403

产品详细信息

Peptide sequence: RLQFGRAPTL PGSAATLQLD GLARAPGQPK IDHLRRLHLG ACPTEECKAC

Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 93%

靶标信息

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.

Life (Basel, Switzerland)

Li H,Li K,Shu D,Shen M,Tan Z,Zhang W,Pu D,Tan W,Tang Z,Jin A,Liu S

Published figure using THRAP5 polyclonal antibody (Product # PA5-40517) in Western Blot

Tue Sep 20 00:00:00 EDT 2022

MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.

Life (Basel, Switzerland)

Li H,Li K,Shu D,Shen M,Tan Z,Zhang W,Pu D,Tan W,Tang Z,Jin A,Liu S

Published figure using THRAP5 polyclonal antibody (Product # PA5-40517) in Western Blot

Tue Sep 20 00:00:00 EDT 2022

MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.

Life (Basel, Switzerland)

Li H,Li K,Shu D,Shen M,Tan Z,Zhang W,Pu D,Tan W,Tang Z,Jin A,Liu S

Published figure using THRAP5 polyclonal antibody (Product # PA5-40517) in Western Blot

Tue Sep 20 00:00:00 EDT 2022

生物信息学

蛋白别名: DRIP92; Mediator complex subunit 16; Mediator of RNA polymerase II transcription subunit 16; thyroid hormone receptor associated protein 5; Thyroid hormone receptor-associated protein 5; thyroid hormone receptor-associated protein 95; Thyroid hormone receptor-associated protein complex 95 kDa component; thyroid hormone receptor-associated protein, 95-kD subunit; Trap95; Vitamin D3 receptor-interacting protein complex 92 kDa component

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基因别名: 95kDa; A630083L04; DRIP92; MED16; THRAP5; TRAP95

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UniProt ID: (Human) Q9Y2X0

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Entrez Gene ID: (Human) 10025, (Mouse) 216154

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功能

transcription cofactor activity transcription coactivator activity catalytic activity receptor activity protein binding thyroid hormone receptor coactivator activity vitamin D receptor binding thyroid hormone receptor binding

参与通路

regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of receptor activity transcription, DNA-templated regulation of transcription, DNA-templated