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Invitrogen
TIA-1 Recombinant Rabbit Monoclonal Antibody (JM42-11)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 10
TIA-1 Antibody (MA5-32615) in ICC/IF
Immunocytochemistry analysis of TIA-1 with A431 cells (red). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS (10 min, room temp) and blocked with 1% Blocker BSA (15 min, room temp), incubated with recombinant monoclonal TIA-1 (Product # MA5-32615) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS, followed by Alexa Fluor 594 Goat anti-Rabbit IgG at 1:1,000 dilution. DAPI was used to stain the cell nuclei (blue).
产品信息
MA5-32615
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM42-11
抗原
Synthetic peptide within Human TIA1 aa 353-386
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809892
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytotoxic granule associated RNA binding protein TIA1; cytotoxic granule-associated RNA-binding protein 1; Nucleolysin TIA-1; Nucleolysin TIA-1 isoform p40; p40 TIA 1; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA 1; TIA-1; TIA1 protein; TIAL1; TIAR
基因别名: 2310050N03Rik; AI256674; mTIA-1; Tia; TIA-1; TIA1; WDM
UniProt ID: (Human) P31483, (Mouse) P52912
Entrez Gene ID: (Human) 7072, (Mouse) 21841
apoptotic process
fibroblast growth factor receptor signaling pathway
negative regulation of translation
negative regulation of cytokine biosynthetic process
regulation of mRNA splicing, via spliceosome
protein localization to cytoplasmic stress granule
positive regulation of epithelial cell apoptotic process
