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产品信息
PA5-40708
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human ZFP36L2 (aa 36-85).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2609141
产品详细信息
Peptide sequence: VGTPVAAAPS SGFAPGFLRR HSASNLHALA HPAPSPGSCS PKFPGAANGS
Sequence homology: Cow: 92%; Guinea Pig: 85%; Mouse: 84%; Rat: 84%
靶标信息
TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Butyrate response factor 2; EGF-response factor 2; ERF-2; mRNA decay activator protein ZFP36L2; Protein TIS11D; TISD; TPA-induced sequence 11d; ZFP36 ring finger protein-like 2; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; Zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 2
基因别名: BRF2; ERF-2; ERF2; RNF162C; TIS11D; ZFP36L2
UniProt ID: (Human) P47974
Entrez Gene ID: (Human) 678
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of transcription, DNA-templated
mRNA catabolic process
cell proliferation
response to wounding
hemopoiesis
T cell differentiation in thymus
somatic stem cell population maintenance
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
negative regulation of fat cell differentiation
somatic stem cell division
definitive hemopoiesis
3'-UTR-mediated mRNA destabilization
ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
cellular response to phorbol 13-acetate 12-myristate
negative regulation of stem cell differentiation
