Invitrogen

TLR1 Polyclonal Antibody

TLR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TLR1 Antibody (PA5-23097) in IHC (P)

Immunohistochemical analysis of TLR1 in human small intestine. Samples were incubated in TLR1 polyclonal antibody (Product # PA5-23097) using a dilution of 10 µg/mL.

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产品信息

PA5-23097

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

免疫组化（石蜡） (IHC (P))

10 µg/mL

流式细胞分析 (Flow)

2-4 µg per million cells

点杂交 (DB)

Assay-Dependent

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A KLH-conjugated synthetic peptide corresponding to a sequence within amino acids 400-450 of human TLR1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2540624

产品详细信息

Suggested positive control: antigen standard for TLR1 (transient overexpression lysate), Ramos.

靶标信息

TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。