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产品信息
TLR-101AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 200-250 on mouse toll-like receptor 1 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
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生物信息学
蛋白别名: CD281; TIL; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
基因别名: CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1
UniProt ID: (Human) Q15399, (Mouse) Q9EPQ1
Entrez Gene ID: (Human) 7096, (Mouse) 21897, (Rat) 305354
microglial cell activation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
defense response
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
response to bacterial lipoprotein
toll-like receptor 1 signaling pathway
macrophage activation
detection of triacyl bacterial lipopeptide
positive regulation of tumor necrosis factor biosynthetic process
innate immune response
positive regulation of interleukin-6 biosynthetic process
regulation of cytokine secretion
cellular response to triacyl bacterial lipopeptide
toll-like receptor TLR1:TLR2 signaling pathway
defense response to bacterium
