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产品信息
TLR-601AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Cat,
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 195-225 on human TLR6 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD antigen 286; CD286; Toll-like receptor 6
基因别名: CD286; TLR-6; TLR6
UniProt ID: (Human) Q9Y2C9, (Mouse) Q9EPW9
Entrez Gene ID: (Pig) 396621, (Cat) 493662, (Human) 10333, (Mouse) 21899, (Rat) 305353
microglial cell activation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
response to bacterial lipoprotein
toll-like receptor 6 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of interleukin-6 biosynthetic process
nitric oxide metabolic process
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
activation of NF-kappaB-inducing kinase activity
toll-like receptor TLR6:TLR2 signaling pathway
defense response to bacterium
interleukin-1 beta secretion
positive regulation of NLRP3 inflammasome complex assembly
