Invitrogen

TLR9 Monoclonal Antibody (5G5), Biotin

查看其他36个TLR9抗体

产品信息

MA5-49116

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:50

-

抑制试剂 (IA)

1:50

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

5G5

抗原

Purified fusion protein of extracellular domain of human TLR9 (AA 1-815) and human IgGFc

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein G

保存液

PBS with 0.1% BSA

内含物

0.02% sodium azide

保存条件

4° C

运输条件

Wet ice

RRID

AB_3093955

产品详细信息

The monoclonal antibody 5G5 reacts with RAW macrophages and TLR9 transfected HEK293 cells, and is cross reactive with canine TLR9.

靶标信息

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD289; Toll-like receptor 9

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基因别名: CD289; TLR9; UNQ5798/PRO19605

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UniProt ID: (Human) Q9NR96, (Mouse) Q9EQU3

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Entrez Gene ID: (Human) 54106, (Mouse) 81897

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transmembrane signaling receptor activity interleukin-1 receptor binding 1-phosphatidylinositol-3-kinase activity siRNA binding protein binding unmethylated CpG binding

参与通路

microglial cell activation regulation of protein phosphorylation toll-like receptor signaling pathway response to molecule of bacterial origin immune system process regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway inflammatory response immune response signal transduction I-kappaB phosphorylation response to virus positive regulation of autophagy positive regulation of gene expression maintenance of gastrointestinal epithelium negative regulation of NF-kappaB transcription factor activity tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of interferon-gamma biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of NF-kappaB transcription factor activity defense response to virus positive regulation of nitric-oxide synthase biosynthetic process negative regulation of calcium-transporting ATPase activity axonogenesis phosphatidylinositol-3-phosphate biosynthetic process defense response to bacterium positive regulation of JNK cascade